Endocrine Abstracts

Introduction: Plasma metanephrines (PMETS) are widely used as a first-line investigation for phaeochromocytoma/paraganglioma owing to the high diagnostic sensitivity of the test. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has become the methodology of choice for measuring PMETS due to the high analytical specificity of the technique. However, there have been recent reports of interference in LC-MS/MS PMETS assays by the α1-recept...

Introduction: Plasma metanephrines (PMETS) are widely used as a first-line investigation for phaeochromocytoma/paraganglioma owing to the high diagnostic sensitivity of the test. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has become the methodology of choice for measuring PMETS due to the high analytical specificity of the technique. However, there have been recent reports of interference in LC-MS/MS PMETS assays by the α1-recept...

Background: A range of laboratory tests are available for investigation of phaeochromocytoma/paraganglioma (PPGL) and there is scope for significant variation in practice between centres. Endocrine Society Clinical Practice Guidelines make recommendations concerning the laboratory investigation of PPGL. We performed a national audit using these recommendations as audit standards.Methodology: A questionnaire was distributed to all clinical biochemistry de...

Introduction: Measurement of plasma metanephrines (PMETS) is widely regarded as one of the best screening tests for phaeochromocytoma/paraganglioma (P/PGL). Current Endocrine Society guidelines recommend that samples for PMETS are ideally collected in the supine position after 30 min rest and interpreted using supine reference ranges, in order to optimise the diagnostic performance of the test. Current practice in our centre is to collect samples for PMETS from seated patients...